Fluoroquinolones Warnings & Side Effects – What You Need to Know

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Fluoroquinolones are broad-spectrum antibiotics that have been used to treat infections of varying types and severity since the 1980s. They are well-tolerated by most patients; however, a growing body of evidence has linked fluoroquinolone use to rare but disabling, and potentially permanent, side effects involving tendons, peripheral nerves, and the central nervous system (CNS). Cardiac, gastrointestinal (GI), metabolic (glucose), and ocular side effects, as well as allergic reactions, have also been reported. In May 2016, the FDA determined that the risks of fluoroquinolone use for certain uncomplicated infections are generally greater than the benefits when other treatment options are available.

Subsequently, the labels of all systemic (oral and injectable) fluoroquinolones were updated with strengthened warnings, including a revised boxed warning. The revisions include “limitation of use” statements advising that, in the treatment of acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, and uncomplicated urinary tract infections (UTIs), fluoroquinolones should be reserved for patients who have no other options.

This issue reviews uncommon but serious side effects of systemic fluoroquinolones. Dosing considerations, use in children and during pregnancy, and potential drug interactions are also discussed…

Authors:

Cherie Dillon, PharmD is the Director of Drug Information and a clinical pharmacy specialist, Veterans Affairs Northern California Health Care System; and an Associate Editor for The Rx Consultant and Continuing Education Network, Inc.

Tracy Farnen, PharmD is the Managing Editor for The Rx Consultant and Continuing Education Network, Inc.

Pamela Mausner, MD is a medical writer and an Associate Editor for The Rx Consultant and Continuing Education Network, Inc.

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