Long-term Metformin Use Prevents Type 2 Diabetes

Share This Post

Share on facebook
Share on linkedin
Share on twitter
Share on email
Results from the long-term follow-up of participants in the landmark Diabetes Prevention Program (DPP) that enrolled patients between 1996 and 2001 were recently published. Metformin use over 15 years was compared to placebo in patients who were at high risk for developing diabetes. A new type 2 diabetes diagnosis was indicated using fasting glucose or 2-hour glucose tolerance as in the original study, or by measuring A1C. Patients who continued to take metformin had a 17% lower risk of developing diabetes or a 36% lower risk if diagnosed by A1C. Even stronger diabetes prevention effects were seen in some subgroups. Women with a history of gestational diabetes had a 41% lower risk compared to women who did not have gestational diabetes. Patients with higher baseline fasting glucose or A1C also benefited more from taking metformin.

Metformin is inexpensive and usually well tolerated. It should be considered for diabetes prevention, particularly for patients with an elevated baseline A1C and for women who had gestational diabetes.

• Diabetes Prevention Program Research Group. Diabetes Care 2019;42:601-608.

More To Explore

What is The Rx Consultant?

The Rx Consultant is a subscription-based service that delivers practical updates & reviews covering all the top-selling drugs and common health conditions. All our publications focus on the facts busy front-line pharmacists and other health care practitioners need to stay current, and provide it a streamlined, easy reading style.

For 30 years The Rx Consultant has operated independent of the pharmaceutical industry and has no commercial bias.

Join thousands of healthcare providers who enjoy the following benefits every month.

1. Drug Therapy Updates & Reviews

The eLibrary contains over 30 streamlined updates on drug therapy for the most common diseases. New articles are added every month – it is a continually expanding resource.

2. Continuing Education

The eLibrary includes 50+ hours of Pharmacology CE from an ACPE approved provider at no additional charge. Each article provides at least 1.5 hours of Pharmacology CE. Subscribers can take their tests online, score them immediately, then print or save their credit statements. Pharmacology CE tests can also be mailed, faxed, or even phoned in to The Rx Consultant office, and credit statements will be delivered by mail or fax.

3. Unlimited Access to our Resource Library, with:

  • Healthcare News

    The eLibrary includes a news column covering the developments that matter most to nurse practitioners and other front-line providers. You get a headline, the bottom line, and how it’s likely to affect your practice in a few short lines, then it’s on to the next news item. The news briefs are also available in print monthly as Rx News Connection.
  • Patient Education Pages

    Patient Q&A to sharpen your skills in educating patients and answering common questions.
  • Charts & Tables

    At-a-glance updates on drugs, doses, common side effects & interactions
  • Quick Facts

    Key facts organized for fast access both online and on handy reference cards.
  • The Bottom Line

    Our members suggest the topics and each issue undergoes a rigorous three month peer reviewed process. Our CE is different because we accept no grants, advertising, or funding of any kind from drug manufacturers. With no financial ties, maintaining a bias-free publication is a straightforward process.

The Rx Consultant maintains a high standard for quality

And a rigorous system for content development that insures it. Every issue is written by an expert in the topic area, and then peer reviewed, fact-checked and edited to insure that the content is

  • Evidence-based
  • Non-Biased
  • Balanced
  • Timely
  • Accurate and
  • Useful for community practitioners

The Rx Consultant is completely independent of the pharmaceutical industry.

We accept no grants, advertising, or funding of any kind from drug manufacturers. With no financial ties, maintaining a bias-free publication is a straightforward process.